This high-resolution array design contains an unprecedented >6.0 million probes covering coding transcripts and non-coding transcripts. HTA 2.0 maximizes the amount of unique and valuable information possible by minimizing the conserved sequence synthesized on the array. HTA 2.0 provides superior accuracy and precision coupled with the most comprehensive view of the transcriptome.īioinformatics built into the array design no assembly required See the HTA 2.0 Flyer in the Documents Section below for additional information. UCSC Known Genes UCSC lincRNA transcripts lncRNA dbīroad Institute, Human Body Map lincRNAs, and TUCP (transcripts of uncertain coding potential) catalogīetter data than 2 full lanes of sequencing RefSeq Vertebrate Genome Annotation (Vega) databaseĮnsembl MGC Mammalian Gene Collection (v10) HTA 2.0 has combined multiple data sources to ensure you are able to independently analyze the broadest collection of transcript isoforms available.ĭata sources used to design and annotate the array Most genes produce multiple transcript isoforms, and measuring changes in the relative abundance of each isoform provides new insights into disease and biology. Until now, measuring and analyzing these transcript isoforms has been nearly impossible due to technology limitations, sample input requirements, and lack of analysis capabilities/tools.Ĭomprehensive transcriptome analysis requires combining transcript diversity from multiple data sources These transcript isoforms are produced when the exons of a gene may be included within, or excluded from, the final, processed messenger RNA produced from that gene. Research has shown that the tens of thousands of human genes contain hundreds of thousands of exons, which produce hundreds of thousands of different transcript isoforms. View the data sheet for details on HTA 2.0 content and coverage.Ĭomprehensive exploration of the transcriptome Designed to empower next-generation expression profiling studies, GeneChip™ Human Transcriptome Array 2.0 provides the ability to go beyond gene-level expression profiling by providing the coverage and accuracy required to accurately detect all known transcript isoforms produced by a gene.
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